2026

Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis. Dyckow-Schubart J., Rabitsch A.M., Geywitz C., Mayer C., Lerma-Martin C., Ludwig N., Smith M., Potschka H., Calabresi P.A., Nave K.A., Friese M.A., Möbius W., Schirmer L. Commun Biol. 9, 849 (2026).

The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis. Rosenkranz S.C., da Rocha J.F., Moreira L., Schlachter P., Bier J., Healy K., Silva D.N., Iqbal M.A., Gharagozloo M., Xiong Y., Murphy M.A., Lichtenfeld H.C., Raich L., Schweizer M., Ertaş A., Woo M.S., Vieira V., Honeycutt S.E., White J.P., Wyant G.A., Friese M.A., Calabresi P.A., Sîrbulescu R.F., Wrann C.D. Nat Metab. 8, 1051-1066 (2026).

Multiple signaling events are required for NAADP synthesis by DUOX2 and formation of Ca2+ microdomains to initiate T cell activation. Winterberg K.J., Schwentner V., Gu F., Möckl F., Li G., Bauche A., Etzold S., Rosche A., Weiß M., Thuille N., Förster F., Woelk L., Werner R., Kovacevic D., Fehse B., Kurelic R., Nawrocki M., Huber S., Mittrücker H.W., Meier C., Müller C.E., Baier G., Skålhegg B.S., de Deken X., Wahl-Schott C., Mair T., Siebels B., Cugota Canals R., Odoardi F., Lodygin D., Flügel A., Nikolaev V.O., Diercks B.P., Guse A.H. Sci Signal. 19, eadp4326 (2026).

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation. de la Rosa C., Kendirli A., Baygün S., Bauernschmitt F., Thomann A.S., Kisioglu I., Beckmann D., Carpentier Solorio Y., Pfaffenstaller V., Tai Y.H., Mehraein N., Sanchez P., Spieth L., Gerdes L.A., Beltran E., Dornmair K., Simons M., Peters A., Schmidt-Supprian M., Kerschensteiner M. Nat Neurosci. 29, 493-509 (2026).

2025

Polyglutamylation of microtubules drives neuronal remodeling. Gavoci A., Zhiti A., Rusková M., Magiera M.M., Wang M., Ziegler K.A., Hausrat T.J., Ugwuja A.I., Chakraborty S., Engelhardt S., Kneussel M., Balastik M., Janke C., Misgeld T., Brill M.S. Nat Commun. 16, 5384 (2025).

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis. Woo M.S., Brand J., Bal L.C., Moritz M., Walkenhorst M., Vieira V., Ipenberg I., Rothammer N., Wang M., Dogan B., Loreth D., Mayer C., Nagel D., Wagner I., Pfeffer L.K., Landgraf P., van Ham M., Mattern K.M., Winschel I., Frantz N., Sonner J.K., Grosshans H.K., Miguela A., Bauer S., Meurs N., Müller A., Binkle-Ladisch L., Salinas G., Jänsch L., Dieterich D.C., Riedner M., Krüger E., Heppner F.L., Glatzel M., Puelles V.G., Engler J.B., Nyengaard J.R., Misgeld T., Kerschensteiner M., Merkler D., Meyer-Schwesinger C., Friese M.A. Cell. 188, 4567-4585.e32 (2025).