2026

Multiple signaling events are required for NAADP synthesis by DUOX2 and formation of Ca2+ microdomains to initiate T cell activation. Winterberg K.J., Schwentner V., Gu F., Möckl F., Li G., Bauche A., Etzold S., Rosche A., Weiß M., Thuille N., Förster F., Woelk L., Werner R., Kovacevic D., Fehse B., Kurelic R., Nawrocki M., Huber S., Mittrücker H.W., Meier C., Müller C.E., Baier G., Skålhegg B.S., de Deken X., Wahl-Schott C., Mair T., Siebels B., Cugota Canals R., Odoardi F., Lodygin D., Flügel A., Nikolaev V.O., Diercks B.P., Guse A.H. Sci Signal. 19, eadp4326 (2026).

2025

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation. de la Rosa C., Kendirli A., Baygün S., Bauernschmitt F., Thomann A.S., Kisioglu I., Beckmann D., Carpentier Solorio Y., Pfaffenstaller V., Tai Y.H., Mehraein N., Sanchez P., Spieth L., Gerdes L.A., Beltran E., Dornmair K., Simons M., Peters A., Schmidt-Supprian M., Kerschensteiner M. Nat Neurosci. NA, NA (2025).

Polyglutamylation of microtubules drives neuronal remodeling. Gavoci A., Zhiti A., Rusková M., Magiera M.M., Wang M., Ziegler K.A., Hausrat T.J., Ugwuja A.I., Chakraborty S., Engelhardt S., Kneussel M., Balastik M., Janke C., Misgeld T., Brill M.S. Nat Commun. 16, 5384 (2025).

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis. Woo M.S., Brand J., Bal L.C., Moritz M., Walkenhorst M., Vieira V., Ipenberg I., Rothammer N., Wang M., Dogan B., Loreth D., Mayer C., Nagel D., Wagner I., Pfeffer L.K., Landgraf P., van Ham M., Mattern K.M., Winschel I., Frantz N., Sonner J.K., Grosshans H.K., Miguela A., Bauer S., Meurs N., Müller A., Binkle-Ladisch L., Salinas G., Jänsch L., Dieterich D.C., Riedner M., Krüger E., Heppner F.L., Glatzel M., Puelles V.G., Engler J.B., Nyengaard J.R., Misgeld T., Kerschensteiner M., Merkler D., Meyer-Schwesinger C., Friese M.A. Cell. 188, 4567-4585.e32 (2025).