PZ1 - Central project
Translational neuropathology and novel tissue methods platform
The project will to provide the tools and patient cohorts to enable researchers of the respective NeuroFlame subprojects to assess molecules of interest in a disease context using, e.g., multiplex immunohistochemistry and spatial transcriptome assessment. Additionally, the project will generate spatial transcriptome data in human diseases of interest to the researchers of the consortium that then feed back to the individual subprojects to inform on potential disease-relevant targets.
Principal investigators
Project team
Leila Dehghan
Research assistant
Dagmar Drexler
Research assistant
Zhezhang Liu
PhD student
Publications
The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis. Woo M.S., Bal L.C., Winschel I. et al. J Clin Invest. 134, e177692 (2024).
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. Woo M.S., Mayer C., Binkle-Ladisch L. et al. Cell. 187, 4043-4060.e30 (2024).
A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease. Sepulveda-Falla D., Chavez-Gutierrez L., Portelius E. et al. Acta Neuropathol. 141, 217-233 (2021).
