Paper | May 21, 2026
Exercise hormone against neuroinflammation
Project P06 published a study demonstrating that the exercise-induced hormone irisin mediates the neuroprotective benefits of aerobic exercise in a mouse model of multiple sclerosis (MS). The researchers showed that irisin helps protect neurons from inflammation-driven damage, preserves synapses and mitochondrial function, and reduces disease severity without altering immune responses. These findings identify irisin as a promising therapeutic candidate for slowing neurodegeneration in MS.
Publications
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis. Rosenkranz S.C., da Rocha J.F., Moreira L. et al. Nat Metab. 8, 1051-1066 (2026).
