Jan Broder Engler
Jan Broder Engler studied medicine at the Charité – Universitätsmedizin Berlin and at the Universidad de Córdoba, Spain. He earned his MD in 2010 with a thesis on autoaggressive and regulatory T cells in systemic lupus erythematosus, conducted at the German Rheumatism Research Centre Berlin (DRFZ).
In 2011, he joined the Institute of Neuroimmunology and Multiple Sclerosis (INIMS) at the University Medical Center Hamburg-Eppendorf (UKE) to pursue mechanistic studies of immune tolerance. In 2015, he completed a PhD in Human Biology focusing on mechanisms of pregnancy-induced immune tolerance in a multiple sclerosis model.
As a postdoctoral researcher, he investigated neuronal responses to inflammation using cell type–specific transcriptional profiling to identify neuroprotective strategies. In 2020, he was awarded a fellowship from the Hertie Network of Excellence in Clinical Neuroscience and became a Senior Scientist at INIMS in 2021.
Since then, his work has focused on epigenetics and ferroptosis in neuroinflammation, as well as exploring gene therapy approaches to establish immune tolerance. Additionally, he develops open-source software tools (e.g., tidyplots) that enable scientists to create publication-quality visualizations directly from code.
Within FOR 5705, his research interest lies in the role of the epigenetic regulator G9a in neuronal vulnerability to inflammatory stress.
Publications
Tidyplots empowers life scientists with easy code-based data visualization. Engler J.B. Imeta. 4, e70018 (2025).
Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis. Winschel I., Willing A., Engler J.B. et al. Biol Sex Differ. 15, 41 (2024).
MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration. Winkler I., Engler J.B., Vieira V. et al. Sci Adv. 9, eadi6855 (2023).
G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis. Rothammer N., Woo M.S., Bauer S. et al. Sci Adv. 8, eabm5500 (2022).
Bassoon proteinopathy drives neurodegeneration in multiple sclerosis. Schattling B., Engler J.B., Volkmann C. et al. Nat Neurosci. 22, 887-896 (2019).
Links
Institute of Neuroimmunology and Multiple Sclerosis
Institution
Hamburg
