Andreas H. Guse
Andreas Guse studied chemistry, biology and pedagogics at the Universitiy of Hamburg, and received his PhD (Dr. rer. nat.) from the Department of Chemistry in 1990. From 1990 to 1993, Andreas was Laboratory Head at the Max-Planck-Society, Clinical Research Groups for Rheumatology, Erlangen, Germany. In 1993 he received his Habilitation in Biochemistry (Dr. med. habil.) at the Friedrich-Alexander-University of Erlangen-Nürnberg, Germany. He established his own laboratory end of 1993 and served as group leader at the Institute of Biochemistry and Molecular Biology I at University Medical Centre Hamburg-Eppendorf (UKE) until 2013. He was appointed Privatdozent in 1994 and Professor in 2000. Since 2013 he is Full Professor and Director of the Department of Biochemistry and Molecular Cell Biology (IBMZ), at UKE. Since 2007 he also serves as Vice-Dean of Education and Students’ Affaires at the Medical Faculty/UKE. He has been speaker of Collaborative Research Center SFB1328 Adenine Nucleotides in Immunity and Inflammation (https://www.sfb1328.de) since 2018. Since 2020 he also has served as president of the European Calcium Society (ECS). His laboratory, The Calcium Signalling Group, focuses on intracellular signaling mechanisms, with emphasis on calcium signaling. Within FOR 5705 he investigates, together with Marc Freichel (Heidelberg), calcium signaling evoked by the second messenger NAADP downstream of glutamate-mediated excitotoxicity.
Publications
Multiple signaling events are required for NAADP synthesis by DUOX2 and formation of Ca2+ microdomains to initiate T cell activation. Winterberg K.J., Schwentner V., Gu F. et al. Sci Signal. 19, eadp4326 (2026).
MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP. Krukenberg S., Möckl F., Weiß M. et al. Nat Commun. 15, 8008 (2024).
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation. Gu F., Krüger A., Roggenkamp H.G. et al. Sci Signal. 14, eabe3800 (2021).
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation. Roggenkamp H.G., Khansahib I., Hernandez C L.C. et al. Sci Signal. 14, eabd5647 (2021).
2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist. Fliegert R., Bauche A., Wolf Pérez A.M. et al. Nat Chem Biol. 13, 1036-1044 (2017).
Links
Department of Biochemistry and Molecular Cell Biology
Institution
Hamburg
