Project P04
Interaction

Michael Kreutz

Michael R. Kreutz studied psychology, philosophy and linguistics at the University of Münster and then performed his PhD studies in Behavioral Neurosciences at the Ruhr University in Bochum. Subsequently he became a research fellow at the Department of Brain and Cognitive Sciences at MIT. From 1990 to 1993 he was staff scientist in the Department of Molecular Neuroendocrinology at the Max Planck Institute for Experimental Medicine in Göttingen. In 1993 he moved to Magdeburg where is currently head of the Neuroplasticity research group at the Leibniz Institute for Neurobiology. He has a second affiliation at the Center for Molecular Neurobiology (ZMNH) in Hamburg where he is heading the Leibniz Group ‘Dendritic Organelles and Synaptic Function’. His research interest is in synapse biology. His work is concerned with fundamental questions on how synapses communicate with the nucleus, how gene activity-dependent gene expression feeds back to synaptic function, how this is related to the formation of a cellular engram and last but not least how the nanoscale organization of the synapse determines functional properties in the context of learning and memory. Finally, the teams in Hamburg and Magdeburg put strong emphasis on translational aspects of their work in the context of neurodegeneration and neuroinflammation.

Publications

Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease. Grochowska K.M., Gomes G.M., Raman R. et al. EMBO J. 42, e112453 (2023).

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. Andres-Alonso M., Ammar M.R., Butnaru I. et al. Nat Commun. 10, 5448 (2019).

Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines. Mikhaylova M., Bär J., van Bommel B. et al. Neuron. 97, 1110-1125.e14 (2018).

A Dendritic Golgi Satellite between ERGIC and Retromer. Mikhaylova M., Bera S., Kobler O., Frischknecht R. & Kreutz M.R. Cell Rep. 14, 189-99 (2016).

Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Karpova A., Mikhaylova M., Bera S. et al. Cell. 152, 1119-33 (2013).